Our lab studies how the brain learns to control the timing of actions. Using reaction-time tasks and related behavioral paradigms, including self-timed tasks, we investigate the neural basis of stimulus-response learning, rapid action initiation, forelimb and whole-body motor control, and interval timing.
We combine behavioral analysis, circuit manipulation, and neural recording. Our current focus is on chronic Neuropixels recordings in the basal ganglia and frontal cortex of rats as they learn, beginning with their first exposure to a behavioral training box or maze and continuing over weeks to months. During this time, animals may encounter changes in task structure or learn multiple tasks in different settings. By tracking the same neurons throughout learning, we can address previously intractable questions about how neural circuits change as new behaviors are acquired.
Our research employs multiple behavioral paradigms to uncover how multiple brain areas collectively learn and produce single behaviors—a 'one behavior, multiple brain structures' approach. We also investigate how individual brain regions contribute to related actions with shared underlying structures, such as reactive responses involving lever release or poke-out.
See examples here:
Operant box: https://youtu.be/FS96rA9onX8
Shuttling maze: https://youtu.be/sCj9ZE06ys8
We believe that behavioral studies should precede neural recordings. Towards this end, we have developed several perturbation strategies to examine the role of specific brain regions in behavior.
We use chronic recordings with silicon probes, including Neuropixels probes, to monitor the activity of large neuron populations over days and weeks—often tracking the same neurons—during both stable behavioral performance and learning.
See an example here: https://youtu.be/tzxtNY9HsgE
Contact
Room 307, Lui Che Woo Building Peking University